Mounjaro (tirzepatide), a new drug for Type 2 Diabetes by Eli Lilly 

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FDA approved this novel, dual-targeted treatment for type 2 diabetes. The manufacturer reported that this drug proved more effective in clinical trials than other therapies evaluated. This injection could improve blood sugar control in adults with type 2 diabetes who practise diet and exercise. Mounjaro was effective at improving blood sugar and was more effective …

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Sunlenca, a new drug release by Gilead Sciences to treat HIV disease

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Sunlenca (lenacapavir) is a new type of antiretroviral medication. In late 2022, FDA (the U.S. Food and Drug Administration) approved Sunlenca, a new HIV drug for adults with limited treatment options. This drug is prioritized for the adult patients who are living with human immunodeficiency virus type 1 (HIV-1) and can’t successfully treat their HIV …

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Benefits, Current Status and Challenges of Deuterium in Drug Discovery 

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Substitution of one or more hydrogen atoms with its heavy isotope deuterium, which is called deuteration, provides additional neutron to a molecule. Although it seems to be a subtle change, this structural modification, may improve the pharmacokinetic properties, efficacy and safety of drugs compared with the non-deuterated counterparts. The structural modification by incorporating deuterium into …

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Relationship between gut microbiome and brain

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Irish neurologist John Cryan reported that there was a link between the gut and the human brain. He has been studying this gut/brain axis for decades, very recently in the department of anatomy and neuroscience at University of Cork in Ireland. The discovery of numerous scientists suggests that there are trillions of benevolent bacteria and …

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Neural Mechanisms of General Anesthesia

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General anesthesia, which is administered to surgical patients during operation, shares the similar numerous neurophysiologic traits with the process of natural sleep. The neural mechanisms underlying sleep–wake and general anesthesia can help to understand their interactions and how anesthetics cause reversible loss of consciousness. Pharmacotherapies, especially those which involve the neural substrates associated with sleep–wake …

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How depression causes abnormal brain signals and transcranial magnetic stimulation restores normal flow of signals

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Transcranial magnetic stimulation (TMS) is a widely used technique to treat and cure depression and other mental health conditions. But the mechanism behind this was not fully clear to the doctors and scientists. Electroconvulsive therapy (ECT) is also the most effective treatment to treat and cure depression. But this procedure is conducted under general anaesthesia …

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Artificial Sweeteners May Be More Dangerous for Health

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People avoid sugars due to the fear of weight gain and some other health related problems. They take artificial sweeteners instead of sugar. But according to the World Health Organization (WHO), artificial sweeteners may not help people to lose weight in the long-run, but they have some dangerous health effects. Artificial sweeteners may increase the …

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Patient’s privacy in digital health

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Digital health service is getting popular nowadays in the world. Health authorities and health services record the health information of the patients in the digital database. However, the safety of the digital health records is a burning question in the modern world due to hacking, data breach and data loss. Therefore, AMA (Australian Medical Association) …

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Outbreak of Marburg Virus Disease in Equatorial Guinea

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An outbreak of Marburg virus disease (MVD) occurred in Equatorial Guinea in January 2023. The Ministry of Health and Social Welfare of Equatorial Guinea declared this outbreak on 13 February 2023 after they reported some suspected viral haemorrhagic fever deaths and a positive case in February 2023. What is Marburg virus disease (MVD) Marburg virus …

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Biologically active excipients need clinical investigation

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Dr Md Anawar Hossain What are excipients used in medicine? Pharmaceutical formulation of a drug product consists of the active pharmaceutical ingredient (API) and excipients. The excipients are called inactive ingredients. According to the U.S. Food and Drug Administration (FDA), the excipients are “any component of a drug product other than an active ingredient”. Most …

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